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Hydrogen peroxide is unstable and light sensitive, and therefore it is difficult to maintain a solution at a specified concentration

The results have been compelling enough that Innerbody Labs includes KSM-66 in two of its own formulations

Despite compelling preclinical evidence, clinical translation of Nrf2 activators for MIRI remains in its infancy, with a significant lack of published trial data specifically in this acute setting (summarized in Table 1)

Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group

In normal fibroblasts, 0.1 mM Myo-Ins did not induce significant changes, whereas 1 and 5 mM led to only mild increases in steady-state LC3B-II levels (~ 1120%) without changes in SQSTM1 ( Figure S1 )